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Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Quaternary ammonium compounds have received recent attention due to their potent in vivo antimalarial activity based on their ability to inhibit de novo phosphatidylcholine synthesis. Here we show that in addition to this, heme binding significantly contributes to the antimalarial activity of these...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Biagini, Giancarlo A., Richier, Eric, Bray, Patrick G., Calas, Michèle, Vial, Henri, Ward, Stephen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166076/
https://ncbi.nlm.nih.gov/pubmed/12878523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2584-2589.2003
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