Pharmacokinetics and Metabolism of [(14)C]Viramidine in Rats and Cynomolgus Monkeys

The pharmacokinetics of [(14)C]viramidine, a prodrug of ribavirin, were studied in rats (30 mg/kg of body weight) and monkeys (10 mg/kg) following intravenous (i.v.) and oral administration. The levels of oral absorption and bioavailabilities were 61.7 and 9.91%, respectively, in rats and 43.9 and 1...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Lin, Chin-Chung, Luu, Kenneth, Lourenco, David, Yeh, Li-Tain
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878505/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2458-2463.2003
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