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Pharmacokinetics and Metabolism of [(14)C]Viramidine in Rats and Cynomolgus Monkeys
The pharmacokinetics of [(14)C]viramidine, a prodrug of ribavirin, were studied in rats (30 mg/kg of body weight) and monkeys (10 mg/kg) following intravenous (i.v.) and oral administration. The levels of oral absorption and bioavailabilities were 61.7 and 9.91%, respectively, in rats and 43.9 and 1...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC166067/ https://ncbi.nlm.nih.gov/pubmed/12878505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2458-2463.2003 |
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