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Both Interleukin-4 (IL-4) and IL-4 Receptor α Signaling Contribute to the Development of Hepatic Granulomas with Optimal Antileishmanial Activity

The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(−/−) and IL-4 receptor α(−/−) mice correlates with retarded granuloma maturation and antileishmanial...

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Publicat a:Infect Immun
Autors principals: Stäger, Simona, Alexander, James, Carter, K. Christine, Brombacher, Frank, Kaye, Paul M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166035/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12874364/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.8.4804-4807.2003
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