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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression of both E1 and E2 glycoproteins, is pH-dependent, and can be neutralized by mAbs mapping to amino acids 412...

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Библиографические подробности
Главные авторы: Hsu, Mayla, Zhang, Jie, Flint, Mike, Logvinoff, Carine, Cheng-Mayer, Cecilia, Rice, Charles M., McKeating, Jane A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2003
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC165865/
https://ncbi.nlm.nih.gov/pubmed/12761383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0832180100
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