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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression of both E1 and E2 glycoproteins, is pH-dependent, and can be neutralized by mAbs mapping to amino acids 412...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hsu, Mayla, Zhang, Jie, Flint, Mike, Logvinoff, Carine, Cheng-Mayer, Cecilia, Rice, Charles M., McKeating, Jane A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165865/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12761383/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0832180100
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