Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression of both E1 and E2 glycoproteins, is pH-dependent, and can be neutralized by mAbs mapping to amino acids 412...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Hsu, Mayla, Zhang, Jie, Flint, Mike, Logvinoff, Carine, Cheng-Mayer, Cecilia, Rice, Charles M., McKeating, Jane A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12761383/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0832180100
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