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Noninvasive gene targeting to the brain

Gene therapy of the brain is hindered by the presence of the blood–brain barrier (BBB), which prevents the brain uptake of bloodborne gene formulations. Exogenous genes have been expressed in the brain after invasive routes of administration, such as craniotomy or intracarotid arterial infusion of n...

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Bibliografiske detaljer
Main Authors: Shi, Ningya, Pardridge, William M.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16586/
https://ncbi.nlm.nih.gov/pubmed/10840060
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