BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription

Germ-line mutations of the BRCA2 tumor suppressor gene greatly increase the risk of developing breast and ovarian cancers. Here, we show that wild-type BRCA2, but not a tumor-specific truncated mutant BRCA2, synergizes with the nuclear receptor coactivator p160 GRIP1 to enhance transcriptional activ...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shin, Sook, Verma, Inder M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165853/
https://ncbi.nlm.nih.gov/pubmed/12756300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1132020100
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id pubmed-165853
record_format dspace
spelling pubmed-1658532004-01-21 BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription Shin, Sook Verma, Inder M. Proc Natl Acad Sci U S A Biological Sciences Germ-line mutations of the BRCA2 tumor suppressor gene greatly increase the risk of developing breast and ovarian cancers. Here, we show that wild-type BRCA2, but not a tumor-specific truncated mutant BRCA2, synergizes with the nuclear receptor coactivator p160 GRIP1 to enhance transcriptional activation by androgen receptor (AR). BRCA2 not only associates with AR and GRIP1 but also cooperates with both the histone acetyltransferase P/CAF and BRCA1 to enhance AR- and GRIP1-mediated transactivation. As such, BRCA2 can exert its tumor suppressor function, in part, by modulating androgen signaling, which has been shown to be antiproliferative in a subset of breast cancer cells and particularly implicated in male breast tumors. National Academy of Sciences 2003-06-10 2003-05-19 /pmc/articles/PMC165853/ /pubmed/12756300 http://dx.doi.org/10.1073/pnas.1132020100 Text en Copyright © 2003, The National Academy of Sciences
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Biological Sciences
spellingShingle Biological Sciences
Shin, Sook
Verma, Inder M.
BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
description Germ-line mutations of the BRCA2 tumor suppressor gene greatly increase the risk of developing breast and ovarian cancers. Here, we show that wild-type BRCA2, but not a tumor-specific truncated mutant BRCA2, synergizes with the nuclear receptor coactivator p160 GRIP1 to enhance transcriptional activation by androgen receptor (AR). BRCA2 not only associates with AR and GRIP1 but also cooperates with both the histone acetyltransferase P/CAF and BRCA1 to enhance AR- and GRIP1-mediated transactivation. As such, BRCA2 can exert its tumor suppressor function, in part, by modulating androgen signaling, which has been shown to be antiproliferative in a subset of breast cancer cells and particularly implicated in male breast tumors.
author Shin, Sook
Verma, Inder M.
author_facet Shin, Sook
Verma, Inder M.
author_sort Shin, Sook
title BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
title_short BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
title_full BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
title_fullStr BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
title_full_unstemmed BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
title_sort brca2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
publisher National Academy of Sciences
publishDate 2003
url https://ncbi.nlm.nih.gov/pmc/articles/PMC165853/
https://ncbi.nlm.nih.gov/pubmed/12756300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1132020100
_version_ 1742598834566987776

Registos relacionados