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Toward a detailed computational model for the mammalian circadian clock

We present a computational model for the mammalian circadian clock based on the intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and Rev-Erb α genes. In agreement with experimental observations, the model can give rise to sustained circadian oscillations in co...

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Bibliografski detalji
Glavni autori: Leloup, Jean-Christophe, Goldbeter, Albert
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC165828/
https://ncbi.nlm.nih.gov/pubmed/12775757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1132112100
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