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Toward a detailed computational model for the mammalian circadian clock
We present a computational model for the mammalian circadian clock based on the intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and Rev-Erb α genes. In agreement with experimental observations, the model can give rise to sustained circadian oscillations in co...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC165828/ https://ncbi.nlm.nih.gov/pubmed/12775757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1132112100 |
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