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Defective importin β recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations
The architectural transcription factor SRY (sex-determining region of the Y chromosome) plays a key role in sex determination as indicated by the fact that mutations in SRY are responsible for XY gonadal dysgenesis in humans. Although many SRY mutations reduce DNA-binding/bending activity, it is not...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC165827/ https://ncbi.nlm.nih.gov/pubmed/12764225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1137864100 |
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