Defective importin β recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations

The architectural transcription factor SRY (sex-determining region of the Y chromosome) plays a key role in sex determination as indicated by the fact that mutations in SRY are responsible for XY gonadal dysgenesis in humans. Although many SRY mutations reduce DNA-binding/bending activity, it is not...

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Главные авторы: Harley, Vincent R., Layfield, Sharon, Mitchell, Claire L., Forwood, Jade K., John, Anna P., Briggs, Lyndall J., McDowall, Sharon G., Jans, David A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2003
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC165827/
https://ncbi.nlm.nih.gov/pubmed/12764225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1137864100
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