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NMR structure of the active conformation of the Varkud satellite ribozyme cleavage site

Substrate cleavage by the Neurospora Varkud satellite (VS) ribozyme involves a structural change in the stem-loop I substrate from an inactive to an active conformation. We have determined the NMR solution structure of a mutant stem-loop I that mimics the active conformation of the cleavage site int...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Hoffmann, Bernd, Mitchell, G. Thomas, Gendron, Patrick, Major, François, Andersen, Angela A., Collins, Richard A., Legault, Pascale
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165820/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12782785/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0832440100
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