Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors

The epidermal growth factor receptor (EGFR) is often amplified and rearranged structurally in tumors of the brain, breast, lung, and ovary. The most common mutation, EGFRvIII, is characterized by an in-frame deletion of 801 base pairs, resulting in the generation of a novel tumor-specific epitope at...

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Autori principali: Sampson, John H., Crotty, Laura E., Lee, Samson, Archer, Gary E., Ashley, David M., Wikstrand, Carol J., Hale, Laura P., Small, Clayton, Dranoff, Glenn, Friedman, Allan H., Friedman, Henry S., Bigner, Darell D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC16575/
https://ncbi.nlm.nih.gov/pubmed/10852962
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