Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability

Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia. The HTLV-1 transactivator, Tax, is implicated as the viral oncoprotein. Naïve cells expressing Tax for the first time develop severe cell cycle abnormalities that include increased DNA synthesis, mitotic arre...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Liu, Baoying, Liang, Min-Hui, Kuo, Yu-liang, Liao, Wei, Boros, Imre, Kleinberger, Tami, Blancato, Jan, Giam, Chou-Zen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2003
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12861013/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.15.5269-5281.2003
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