Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability

Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia. The HTLV-1 transactivator, Tax, is implicated as the viral oncoprotein. Naïve cells expressing Tax for the first time develop severe cell cycle abnormalities that include increased DNA synthesis, mitotic arre...

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Detalhes bibliográficos
Main Authors: Liu, Baoying, Liang, Min-Hui, Kuo, Yu-liang, Liao, Wei, Boros, Imre, Kleinberger, Tami, Blancato, Jan, Giam, Chou-Zen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165734/
https://ncbi.nlm.nih.gov/pubmed/12861013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.15.5269-5281.2003
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