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Proliferation Failure and Gamma Radiation Sensitivity of Fen1 Null Mutant Mice at the Blastocyst Stage

Flap endonuclease 1 (FEN1) has been shown to remove 5′ overhanging flap intermediates during base excision repair and to process the 5′ ends of Okazaki fragments during lagging-strand DNA replication in vitro. To assess the in vivo role of the mammalian enzyme in repair and replication, we used a ge...

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Udgivet i:Mol Cell Biol
Principais autores: Larsen, Elisabeth, Gran, Christine, Sæther, Barbro Elisabet, Seeberg, Erling, Klungland, Arne
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165721/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12861020/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.15.5346-5353.2003
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