Proliferation Failure and Gamma Radiation Sensitivity of Fen1 Null Mutant Mice at the Blastocyst Stage

Flap endonuclease 1 (FEN1) has been shown to remove 5′ overhanging flap intermediates during base excision repair and to process the 5′ ends of Okazaki fragments during lagging-strand DNA replication in vitro. To assess the in vivo role of the mammalian enzyme in repair and replication, we used a ge...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Larsen, Elisabeth, Gran, Christine, Sæther, Barbro Elisabet, Seeberg, Erling, Klungland, Arne
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165721/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12861020/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.15.5346-5353.2003
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