WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility

The Wiskott–Aldrich syndrome related protein WAVE2 is implicated in the regulation of actin-cytoskeletal reorganization downstream of the small Rho GTPase, Rac. We inactivated the WAVE2 gene by gene-targeted mutation to examine its role in murine development and in actin assembly. WAVE2-deficient em...

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Main Authors: Yan, Catherine, Martinez-Quiles, Narcisa, Eden, Sharon, Shibata, Tomoyuki, Takeshima, Fuminao, Shinkura, Reiko, Fujiwara, Yuko, Bronson, Roderick, Snapper, Scott B., Kirschner, Marc W., Geha, Raif, Rosen, Fred S., Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2003
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC165620/
https://ncbi.nlm.nih.gov/pubmed/12853475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg350
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