Growth Retardation, Early Death, and DNA Repair Defects in Mice Deficient for the Nucleotide Excision Repair Enzyme XPF

Xeroderma pigmentosum (XP) is a human genetic disease which is caused by defects in nucleotide excision repair. Since this repair pathway is responsible for removing UV irradiation-induced damage to DNA, XP patients are hypersensitive to sunlight and are prone to develop skin cancer. Based on the un...

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Detalhes bibliográficos
Main Authors: Tian, Ming, Shinkura, Reiko, Shinkura, Nobuhiko, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC321450/
https://ncbi.nlm.nih.gov/pubmed/14729965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.3.1200-1205.2004
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