Ubiquitin–proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP

SGK-1 (serum- and glucocorticoid-regulated kinase-1) is a stress-induced serine/threonine kinase that is phosphorylated and activated downstream of PI3K (phosphoinositide 3-kinase). SGK-1 plays a critical role in insulin signalling, cation transport and cell survival. SGK-1 mRNA expression is transi...

Full description

Saved in:
Bibliographic Details
Main Authors: Belova, Larissa, Sharma, Sanjay, Brickley, Deanna R., Nicolarsen, Jeremy R., Patterson, Cam, Conzen, Suzanne D.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1652829/
https://ncbi.nlm.nih.gov/pubmed/16895519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060905
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items