Ubiquitin–proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP

SGK-1 (serum- and glucocorticoid-regulated kinase-1) is a stress-induced serine/threonine kinase that is phosphorylated and activated downstream of PI3K (phosphoinositide 3-kinase). SGK-1 plays a critical role in insulin signalling, cation transport and cell survival. SGK-1 mRNA expression is transi...

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Hauptverfasser: Belova, Larissa, Sharma, Sanjay, Brickley, Deanna R., Nicolarsen, Jeremy R., Patterson, Cam, Conzen, Suzanne D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1652829/
https://ncbi.nlm.nih.gov/pubmed/16895519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060905
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