Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4α (HNF4α) gene

The liver is exposed to a wide variety of toxic agents, many of which damage DNA and result in increased levels of the tumour suppressor protein p53. We have previously shown that p53 inhibits the transactivation function of HNF (hepatocyte nuclear factor) 4α1, a nuclear receptor known to be critica...

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Detalhes bibliográficos
Main Authors: Maeda, Yutaka, Hwang-Verslues, Wendy W., Wei, Gang, Fukazawa, Takuya, Durbin, Mary L., Owen, Laurie B., Liu, Xuan, Sladek, Frances M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1652821/
https://ncbi.nlm.nih.gov/pubmed/16895524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060614
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