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Down-Regulation of Hepatic HNF4α Gene Expression during Hyperinsulinemia via SREBPs
Mutations in the coding region of hepatocyte nuclear factor 4α (HNF4α), and its upstream promoter (P2) that drives expression in the pancreas, are known to lead to maturity-onset diabetes of the young 1 (MODY1). HNF4α also controls gluconeogenesis and lipid metabolism in the liver, where the proxima...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667705/ https://ncbi.nlm.nih.gov/pubmed/19179483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0531 |
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