Development of Antibiotic-Overproducing Strains by Site-Directed Mutagenesis of the rpsL Gene in Streptomyces lividans

Certain rpsL (which encodes the ribosomal protein S12) mutations that confer resistance to streptomycin markedly activate the production of antibiotics in Streptomyces spp. These rpsL mutations are known to be located in the two conserved regions within the S12 protein. To understand the roles of th...

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Veröffentlicht in:	Appl Environ Microbiol
Hauptverfasser:	Okamoto-Hosoya, Yoshiko, Okamoto, Susumu, Ochi, Kozo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Genetics and Molecular Biology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165214/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12839808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.69.7.4256-4259.2003
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