Development of Antibiotic-Overproducing Strains by Site-Directed Mutagenesis of the rpsL Gene in Streptomyces lividans

Certain rpsL (which encodes the ribosomal protein S12) mutations that confer resistance to streptomycin markedly activate the production of antibiotics in Streptomyces spp. These rpsL mutations are known to be located in the two conserved regions within the S12 protein. To understand the roles of th...

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Bibliografske podrobnosti

izdano v:	Appl Environ Microbiol
Principais autores:	Okamoto-Hosoya, Yoshiko, Okamoto, Susumu, Ochi, Kozo
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2003
Teme:	Genetics and Molecular Biology
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165214/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12839808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.69.7.4256-4259.2003
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