Selectable System for Monitoring the Instability of CTG/CAG Triplet Repeats in Mammalian Cells

Despite substantial progress in understanding the mechanism by which expanded CTG/CAG trinucleotide repeats cause neurodegenerative diseases, little is known about the basis for repeat instability itself. By taking advantage of a novel phenomenon, we have developed a selectable assay to detect contr...

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Bibliografiska uppgifter
Huvudupphovsmän: Gorbunova, Vera, Seluanov, Andrei, Dion, Vincent, Sandor, Zoltan, Meservy, James L., Wilson, John H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2003
Ämnen:
DNA Dynamics and Chromosome Structure
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC164839/
https://ncbi.nlm.nih.gov/pubmed/12808091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.13.4485-4493.2003
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