Viability of Poliovirus/Rhinovirus VPg Chimeric Viruses and Identification of an Amino Acid Residue in the VPg Gene Critical for Viral RNA Replication

Picornaviral RNA replication utilizes a small virus-encoded protein, termed 3B or VPg, as a primer to initiate RNA synthesis. This priming step requires uridylylation of the VPg peptide by the viral polymerase protein 3D(pol), in conjunction with other viral or host cofactors. In this study, we comp...

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Detalhes bibliográficos
Main Authors: Cheney, I. Wayne, Naim, Suhaila, Shim, Jae Hoon, Reinhardt, Meghan, Pai, Bharati, Wu, Jim Z., Hong, Zhi, Zhong, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164788/
https://ncbi.nlm.nih.gov/pubmed/12805442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7434-7443.2003
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