Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks

Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly used in mammalian somatic cell genetics or to cure genetic diseases. Recently, it has been demonstra...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Porteus, Matthew H., Cathomen, Toni, Weitzman, Matthew D., Baltimore, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
DNA Dynamics and Chromosome Structure
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC164769/
https://ncbi.nlm.nih.gov/pubmed/12724414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.10.3558-3565.2003
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky