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Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly used in mammalian somatic cell genetics or to cure genetic diseases. Recently, it has been demonstra...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2003
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC164769/ https://ncbi.nlm.nih.gov/pubmed/12724414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.10.3558-3565.2003 |
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