Differential proteasomal processing of hydrophobic and hydrophilic protein regions: Contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef

HIV proteins contain a multitude of naturally processed cytotoxic T lymphocyte (CTL) epitopes that concentrate in clusters. The molecular basis of epitope clustering is of interest for understanding HIV immunogenicity and for vaccine design. We show that the CTL epitope clusters of HIV proteins pred...

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Bibliographic Details
Main Authors: Lucchiari-Hartz, Maria, Lindo, Viv, Hitziger, Niclas, Gaedicke, Simone, Saveanu, Loredana, van Endert, Peter M., Greer, Fiona, Eichmann, Klaus, Niedermann, Gabriele
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC164660/
https://ncbi.nlm.nih.gov/pubmed/12810958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1232228100
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