The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment
It is now accepted that the structural transition from cellular prion protein (PrP(C)) to proteinase K-resistant prion protein scrapie (PrP(Sc)) is the major event leading to transmissible spongiform encephalopathies. Although the mechanism of this transition remains elusive, glycosylation has been...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164631/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12805563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1232504100 |
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