Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice

Mediated by guanylate cyclase-activating proteins (GCAPs), cytoplasmic Ca(2+) levels regulate the activity of photoreceptor guanylate cyclase (GC) and the synthesis of cGMP, the internal transmitter of phototransduction. When GCAP1 is expressed in transgenic mice on a GCAP null background, it restor...

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Bibliographic Details
Main Authors: Pennesi, Mark E., Howes, Kim A., Baehr, Wolfgang, Wu, Samuel M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC164524/
https://ncbi.nlm.nih.gov/pubmed/12732716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1130102100
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