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A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4(+) T cells

Immunization of mice with two myasthenogenic peptides, p195–212 and p259–271, which are sequences of the human acetylcholine receptor, resulted in myasthenia gravis (MG)-associated immune responses. A dual altered peptide ligand (APL) composed of the two APLs of the myasthenogenic peptides inhibited...

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Bibliografiske detaljer
Main Authors: Paas-Rozner, Miri, Sela, Michael, Mozes, Edna
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC164506/
https://ncbi.nlm.nih.gov/pubmed/12743364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1131898100
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