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Oral administration of a dual analog of two myasthenogenic T cell epitopes down-regulates experimental autoimmune myasthenia gravis in mice

Myasthenia gravis (MG) and experimental autoimmune MG (EAMG) are T cell-regulated, antibody-mediated autoimmune diseases. The major autoantigen in MG is the nicotinic acetylcholine receptor (AChR). Two peptides, representing sequences of the human AChR α-subunit, p195–212 and p259–271, were previous...

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Autori principali: Paas-Rozner, Miri, Dayan, Molly, Paas, Yoav, Changeux, Jean-Pierre, Wirguin, Itzhak, Sela, Michael, Mozes, Edna
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC15772/
https://ncbi.nlm.nih.gov/pubmed/10681457
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