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A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4(+) T cells

Immunization of mice with two myasthenogenic peptides, p195–212 and p259–271, which are sequences of the human acetylcholine receptor, resulted in myasthenia gravis (MG)-associated immune responses. A dual altered peptide ligand (APL) composed of the two APLs of the myasthenogenic peptides inhibited...

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Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Paas-Rozner, Miri, Sela, Michael, Mozes, Edna
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 2003
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12743364/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1131898100
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