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Exponential growth by cross-catalytic cleavage of deoxyribozymogens
We have designed an autocatalytic cycle based on the highly efficient 10–23 RNA-cleaving deoxyribozyme that is capable of exponential amplification of catalysis. In this system, complementary 10–23 variants were inactivated by circularization, creating deoxyribozymogens. Upon linearization, the enzy...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC164461/ https://ncbi.nlm.nih.gov/pubmed/12743371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1130145100 |
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