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Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

β-Amyloid (Aβ) acquires toxicity by self-aggregation. To identify and characterize the toxic form(s) of Aβ aggregates, we examined in vitro aggregation conditions by using large quantities of homogenous, chemically synthesized Aβ(1–40) peptide. We found that slow rotation of Aβ(1–40) solution reprod...

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Detalhes bibliográficos
Main Authors: Hoshi, Minako, Sato, Michio, Matsumoto, Shinichiro, Noguchi, Akihiko, Yasutake, Kaori, Yoshida, Natsuko, Sato, Kazuki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164453/
https://ncbi.nlm.nih.gov/pubmed/12750461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1237107100
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