The C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A

Replication of the plus-stranded RNA genome of hepatitis C virus (HCV) occurs in a membrane-bound replication complex consisting of viral and cellular proteins and viral RNA. NS5B, the RNA polymerase of HCV, is anchored to the membranes via a C-terminal 20-amino-acid-long hydrophobic domain, which i...

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Main Authors: Lee, Haekyung, Liu, Ying, Mejia, Edison, Paul, Aniko V., Wimmer, Eckard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1642141/
https://ncbi.nlm.nih.gov/pubmed/16971430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02072-05
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