Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase.

Lobucavir (LBV) is a deoxyguanine nucleoside analog with broad-spectrum antiviral activity. LBV was previously shown to inhibit herpes simplex virus (HSV) DNA polymerase after phosphorylation by the HSV thymidine kinase. Here we determined the mechanism of action of LBV against human cytomegalovirus...

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Detalhes bibliográficos
Main Authors: Tenney, D J, Yamanaka, G, Voss, S M, Cianci, C W, Tuomari, A V, Sheaffer, A K, Alam, M, Colonno, R J
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164188/
https://ncbi.nlm.nih.gov/pubmed/9420038
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