Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase.

Lobucavir (LBV) is a deoxyguanine nucleoside analog with broad-spectrum antiviral activity. LBV was previously shown to inhibit herpes simplex virus (HSV) DNA polymerase after phosphorylation by the HSV thymidine kinase. Here we determined the mechanism of action of LBV against human cytomegalovirus...

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Bibliografske podrobnosti
Main Authors: Tenney, D J, Yamanaka, G, Voss, S M, Cianci, C W, Tuomari, A V, Sheaffer, A K, Alam, M, Colonno, R J
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC164188/
https://ncbi.nlm.nih.gov/pubmed/9420038
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