Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase.

Lobucavir (LBV) is a deoxyguanine nucleoside analog with broad-spectrum antiviral activity. LBV was previously shown to inhibit herpes simplex virus (HSV) DNA polymerase after phosphorylation by the HSV thymidine kinase. Here we determined the mechanism of action of LBV against human cytomegalovirus...

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Bibliographische Detailangaben
Hauptverfasser: Tenney, D J, Yamanaka, G, Voss, S M, Cianci, C W, Tuomari, A V, Sheaffer, A K, Alam, M, Colonno, R J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC164188/
https://ncbi.nlm.nih.gov/pubmed/9420038
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