A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatis.
Ethambutol [EMB; dextro-2,2'-(ethylenediimino)-di-1-butanol] is an effective drug when used in combination with isoniazid for the treatment of tuberculosis. It inhibits the polymerization of arabinan in the arabinogalactan and lipoarabinomannan of the mycobacterial cell wall. Recent studies have sho...
保存先:
| 出版年: | Antimicrob Agents Chemother |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology (ASM)
1997
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164181/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9420031/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.12.2629 |
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