A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatis.
Ethambutol [EMB; dextro-2,2'-(ethylenediimino)-di-1-butanol] is an effective drug when used in combination with isoniazid for the treatment of tuberculosis. It inhibits the polymerization of arabinan in the arabinogalactan and lipoarabinomannan of the mycobacterial cell wall. Recent studies have sho...
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| Published in: | Antimicrob Agents Chemother |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
1997
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164181/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9420031/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.12.2629 |
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