Substrate Dependence of Conformational Changes in the RNA-Binding Domain of Tristetraprolin Assessed by Fluorescence Spectroscopy of Tryptophan Mutants

Association of tristetraprolin (TTP) with mRNAs containing selected AU-rich mRNA-destabilizing elements (AREs) initiates rapid cytoplasmic degradation of these transcripts. The RNA-binding activity of TTP is mediated by an internal tandem zinc finger domain that preferentially recognizes U-rich RNA...

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Main Authors: Brewer, Brandy Y., Ballin, Jeff D., Fialcowitz-White, Elizabeth J., Blackshear, Perry J., Wilson, Gerald M.
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1640280/
https://ncbi.nlm.nih.gov/pubmed/17105199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061320j
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