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Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii.

Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (lead...

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Urbina, J A, Visbal, G, Contreras, L M, McLaughlin, G, Docampo, R
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163934/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9210660/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.7.1428
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