Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii.

Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (lead...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Urbina, J A, Visbal, G, Contreras, L M, McLaughlin, G, Docampo, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163934/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9210660/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.7.1428
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