New quinoline di-Mannich base compounds with greater antimalarial activity than chloroquine, amodiaquine, or pyronaridine.

We have compared the ex vivo antimalarial activity of 12 new quinoline di-Mannich base compounds containing the 7-dichloroquinoline or 7-trifluoromethylquinoline nucleus with amodiaquine, chloroquine, and pyronaridine using the Saimiri-bioassay model. Each compound was administered orally (30 mg/kg...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Kotecka, B M, Barlin, G B, Edstein, M D, Rieckmann, K H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9174201/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.6.1369
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