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Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 recepto...

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Autors principals: Akintunde Sowunmi, Grace O Gbotosho, Christian T Happi, Ahmed A Adedeji, Olayinka M Bolaji, Fatai A Fehintola, Babasola A Fateye, Ayoade MJ Oduola
Format: Artigo
Idioma:Inglês
Publicat: Fundação Oswaldo Cruz (FIOCRUZ) 2007-06-01
Col·lecció:Memorias do Instituto Oswaldo Cruz
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Accés en línia:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000300023
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