Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology

Huntington’s disease is a progressive neurodegenerative disorder caused by a polyglutamine [poly(Q)] repeat expansion in the first exon of the huntingtin protein. Previously, we showed that N-terminal huntingtin peptides with poly(Q) tracts in the pathological range (51–122 glutamines), but not with...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Scherzinger, Eberhard, Sittler, Annie, Schweiger, Katja, Heiser, Volker, Lurz, Rudi, Hasenbank, Renate, Bates, Gillian P., Lehrach, Hans, Wanker, Erich E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200309/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4604
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