The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

Growth factor signaling is mediated through Class IA phosphatidylinositol 3-kinases (PI3Ks). Among this class of enzymes, only p110α, encoded by the PIK3CA gene, has been found to be mutant in human cancers. To determine the specific functions of p110α, we generated mice carrying a conditionally tar...

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Main Authors: Zhao, Jean J., Cheng, Hailing, Jia, Shidong, Wang, Li, Gjoerup, Ole V., Mikami, Aki, Roberts, Thomas M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637576/
https://ncbi.nlm.nih.gov/pubmed/17060635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607899103
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