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The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
Growth factor signaling is mediated through Class IA phosphatidylinositol 3-kinases (PI3Ks). Among this class of enzymes, only p110α, encoded by the PIK3CA gene, has been found to be mutant in human cancers. To determine the specific functions of p110α, we generated mice carrying a conditionally tar...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1637576/ https://ncbi.nlm.nih.gov/pubmed/17060635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607899103 |
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